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|0 (IdRef)196384826
|1 http://www.idref.fr/196384826/id
|a Gupta, Pawan K.
|d (1943-....).
|4 aut.
|e Auteur
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|a Fundamentals of toxicology :
|b essential concepts and applications
|c P. K. Gupta,....
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|a Données textuelles.
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|a London :
|b Academic Press is an imprint of Elsevier,
|c 2016, cop. 2016.
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|b txt
|2 rdacontent
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|a Titre provenant de la p. de titre du document numérisé.
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|a Numérisation de l'édition de London : Academic Press is an imprint of Elsevier, 2016, cop. 2016.
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|a Notice rédigée d'après la consultation, 2016-11-08.
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|a L'impression du document génère 424 p.
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|a Notes bibliogr. Index.
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|a L'accès à cette ressource est réservé aux usagers des établissements qui en ont fait l'acquisition
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|a Navigateur Internet ; lecteur de fichiers PDF.
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|b About the Author
|b Foreword
|b Preface
|b Unit I
|c 1 Introduction and historical background
|d 1.1 Introduction
|d 1.2 Historical Background
|e 1.2.1 Antiquity
|e 1.2.2 Middle Ages
|e 1.2.3 Age of Enlightenment
|d 1.3 Modern Toxicology
|e 1.3.1 After World War II
|c 2 Definitions and scope of toxicology
|d 2.1 Definitions
|d 2.2 Sub-disciplines of Toxicology
|d 2.3 Toxicant and Types of Toxicants
|d 2.4 Toxicity and Toxic Effects
|e 2.4.1 Toxicity in Relation to Frequency and Duration of Exposure
|e 2.4.2 Toxicity in Relation to Time of Development and Duration of Induced Effects
|d 2.5 Dose and Related Terms
|d 2.6 Other Common Terms
|d 2.7 Sources of Poisoning
|e 2.7.1 Accidental Poisoning
|e 2.7.2 Malicious Poisoning
|e 2.7.3 Occupational Exposure
|d 2.8 Duration and Frequency of Exposure
|c 3 Classification of poisons/toxicants
|d 3.1 Introduction
|d 3.2 Classification of Poisons
|d 3.3 Actions of Poisons
|c 4 Factors affecting toxicity
|d 4.1 Introduction
|d 4.2 Factors Affecting Toxicity
|e 4.2.1 Host Factors
|e 4.2.2 Factors Related to the Toxicant or Associated With Xenobiotics
|e 4.2.3 Environmental Conditions
|c 5 Natural laws concerning toxicology
|d 5.1 Introduction
|d 5.2 Tolerance
|d 5.3 Dose
|d 5.4 Time Action Curves
|d 5.5 Dose-Response Relationship
|e 5.5.1 Graded or Gradual Dose-Response Relationship
|e 5.5.2 Quantal or All-or-None Dose-Response Relationship
|d 5.6 Statistical Concept of Toxicity
|d 5.7 Variables of Dose-Response Curve
|d 5.8 Frequently Used Terms for Safety Evaluation of Drugs
|d 5.9 Interaction With Receptors
|d 5.10 Types of Xenobiotics
|d 5.11 Xenobiotic/Drug Interaction
|d 5.12 Nature and Extent of Toxicity Testing
|c 6 Hazard and risk assessment
|d 6.1 Introduction
|d 6.2 Risk Assessment Approach
|e 6.2.1 Preliminary Evaluation
|e 6.2.2 Toxicity Assessment
|e 6.2.3 Exposure Assessment
|d 6.3 Conclusion
|b Unit II
|c 7 Absorption, distribution, and excretion of toxicants
|d 7.1 Introduction
|d 7.2 Translocation of Xenobiotics Across Membranes
|e 7.2.1 Membrane Permeability
|e 7.2.2 Mechanism of Chemical Transfer
|e 7.2.3 Processes of Transport
|f 7.2.3.1 Passive transport
|f 7.2.3.2 Specialized active transport
|f 7.2.3.3 Additional transport processes
|d 7.3 Absorption
|e 7.3.1 Gastrointestinal Absorption
|e 7.3.2 Skin Absorption
|e 7.3.3 Lungs Absorption
|e 7.3.4 Parenteral Administration
|d 7.4 Distribution
|e 7.4.1 Tissue Permeability Barriers
|e 7.4.2 Transfer Across Other Membranes
|e 7.4.3 Factors Affecting Distribution and Tissue Retention
|e 7.4.4 Binding to Biological Macromolecules and Toxic Effects
|e 7.4.5 Redistribution
|d 7.5 Excretion
|e 7.5.1 Renal Excretion
|e 7.5.2 Biliary Excretion
|e 7.5.3 Gastrointestinal Tract
|e 7.5.4 Expired Air
|e 7.5.5 Sweat
|e 7.5.6 Saliva
|e 7.5.7 Milk
|e 7.5.8 Vaginal Secretions
|e 7.5.9 Other Routes
|c 8 Biotransformation
|d 8.1 Introduction
|d 8.2 Functions of Biotransformation
|d 8.3 Xenobiotic Metabolizing Enzymes
|d 8.4 Pathways of Biotransformation
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|0 (IdRef)02779217X
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